Is Regenexx Painful? What to Expect During and After Your Procedure

When it comes to innovative treatments like those offered through Regenexx lab processes, the most common question we hear from patients is, “Is it painful?” At iSCORE, we understand that the idea of a medical procedure can cause some anxiety. However, we aim to ensure that your experience is as comfortable and seamless as possible.

Let's break down what you can expect during and after a Regenexx procedure and address any concerns you might have about pain.


The Process Starts with a Simple Blood Draw

For many Regenexx procedures, the process begins with a simple blood draw. This procedure, which is typically well tolerated by most patients, is used to collect the necessary components to support your treatment. This process is not invasive, and it typically feels similar to any other routine blood draw you might have experienced before.



Regenexx SD Injectate: Bone Marrow Aspirate with Local Anesthesia

If your procedure involves Regenexx SD injectate, which is derived from bone marrow concentrate, there will be a slightly different approach. This procedure involves a bone marrow aspirate.


You might be wondering: What exactly is a bone marrow aspirate? Well, it's important to note that a bone marrow aspirate is a much less invasive process than a bone marrow biopsy. The procedure involves using a small needle to collect bone marrow from your pelvis. Local anesthesia is applied to the area to numb it, ensuring that you’re comfortable throughout the process.


Managing Discomfort During the Procedure

Many patients worry about discomfort during these procedures. Rest assured, the use of local anesthesia is designed to minimize pain. Additionally, some patients are offered an oral sedative to help relax their muscles and ease any anxiety prior to the bone marrow aspirate. This can help create a more relaxed experience and make the procedure even more comfortable.


After the Procedure: What to Expect

After your procedure, there may be some mild soreness at the joint and injection sites. This is common and typically temporary. It’s important to note that any discomfort you experience after the procedure is usually manageable.


In terms of pain management, your physician may recommend over-the-counter pain relievers like acetaminophen, or in some cases, may prescribe pain medication. To allow the body to adjust, you’ll be asked to keep the treated joint as still as possible for 30-60 minutes after the procedure. For the first day following the procedure, it’s also advised that you limit physical activity involving the treated area.


Your physician might suggest using a brace, wrap, or walking boot to support the joint or area treated, which can help reduce stress on the area and promote healing.


Comfort and Care Are Our Priorities

At iSCORE, we are committed to ensuring that your Regenexx procedure is as comfortable as possible. While some soreness and discomfort are to be expected, we use advanced techniques and local anesthesia to minimize pain and help you recover smoothly. The goal is to help you get back to doing what you love without the need for invasive surgeries.


If you have any concerns about pain or the procedure itself, don’t hesitate to reach out to us. We are here to guide you through every step of your treatment and ensure you feel comfortable and informed throughout the process.


Want to learn more or schedule a consultation? Contact iSCORE today, and let us help you take the first step toward your recovery journey.


Contact Us:

  • Arcadia Location: 51 N. 5th Ave Suite A, Arcadia, CA 91006 | (818) 338-6860 | (626) 460-1096
  • Glendale Location: 317 S Brand Blvd Suite A-103, Glendale, CA 91204 | (818) 338-6860 | (626) 460-1096
  • Palmdale Location: 41210 11th Street West, Suite K, Palmdale, CA 93551 | (818) 338-6860 | (626) 460-1096


Let’s get you back on the road to recovery — with as little discomfort as possible!


iSCORE Inc

iSCORE Inc © All rights reserved. 

Arcadia Location

51 N. 5th Ave Suite A, Arcadia, CA 91006

Glendale Location

317 S Brand Blvd Suite A-103, Glendale, CA 91204

Palmdale Location

41210 11th Street West, Suite K, Palmdale, CA 93551

iScore © 2025. All rights reserved.